Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
CLINICAL RADIOBIOLOGY RTP235 3. Semester 2 + 2 2.0 2.0

Prerequisites None

Language of Instruction Turkish
Course Level Associate's Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors Cengiz KURTMAN
Assistants
Goals Radiobiology is the basic science behind radiotherapy and it can explain, and occasionally also predict responses of tumours and normal tissues to radiation. Knowledge of the principles of radiobiology allows the RTT to comprehend the effects of different types of radiation, fractionation schemes, the use of radiosensitizers and other interactions he/she observes on a daily basis. The aim of this course is to inform students about the types of radiation and to explain the effects of radiation on living cells, tissues, systems and metabolisms, and to raise awareness about the use of radiation and protection from radiation. In simplest terms, radiobiology is the study of the action of ionizing radiation on living structures and organisms.
Course Content Basic and Molecular Cell Biology; Cell Cycle/Checkpoints and Radiation sensitivities of different phases in the cell cycle, Dividing cells and the concept of survival; Introduction to Radiobiology, Definition and Types of Radiation; Irradiation-induced damage and DNA damage response; Cell death after irradiation: how, when and why do cells die?; Radiation dose-response relationships; Linear energy transfer (LET) and relative biological efficiency (RBE); Types of cellular damage caused by radiation, Factors affecting the cell survival curve; Effect of radiation on tissues and organs; Tumor kinetics, Model tumor systems, Tumor response to radiation; Late effects of radiation, Genetic effects, Carcinogenic effects, Effects of radiation on embryo and fetus; Radiation protection
Learning Outcomes 1) • Radiobiology is the basic science behind radiotherapy and it can explain, and occasionally also predict responses of tumours and normal tissues to radiation
2) Defines the basic concepts of radiobiology and explains the effect of radiation on the cell.
3) Explain the Effects of Radiation on Cell and Tissue
4) Explains Radiation Exposure Limits

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week introduction to radiobiology Lecture; Question Answer; Discussion; Case Study; Role Play
Brainstorming; Opinion Pool; Colloquium; Debate
Project Based Learning; Scenario Based Learning; Brain Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.) Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice) Internship
2. Week The effect of radiation on tissue and cell Lecture; Discussion; Case Study

Case Based Learning 		Homework Presentation (Including Preparation Time) Activity (Web Search, Library Work, Trip, Observation, Interview etc.) Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice) Internship
3. Week Radiation Carcinogenesis, Hereditary Effects of Radiation Lecture

 Homework
4. Week target theory Lecture; Discussion

Case Based Learning 		Homework Presentation (Including Preparation Time) Internship
5. Week Acute and chronic side effects Lecture

Case Based Learning 		Homework Presentation (Including Preparation Time) Activity (Web Search, Library Work, Trip, Observation, Interview etc.) Internship
6. Week survival curve Lecture; Question Answer; Problem Solving; Demonstration
Workshop
Case Based Learning 		Presentation (Including Preparation Time) Activity (Web Search, Library Work, Trip, Observation, Interview etc.) Internship
7. Week linear qutratic formule Lecture; Discussion
Workshop
Brain Based Learning; Case Based Learning 		Homework Presentation (Including Preparation Time) Activity (Web Search, Library Work, Trip, Observation, Interview etc.) Internship
8. Week mid term exam Problem Solving

 Homework
9. Week cancer biology Lecture
Panel
Storyline 		Homework Presentation (Including Preparation Time) Seminar
10. Week clinical aspects Lecture; Case Study
Debate
Case Based Learning 		Homework Presentation (Including Preparation Time) Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice) Internship
11. Week volume effect, total body radiotherapy Lecture; Question Answer
Buzz Group
Storyline; Case Based Learning 		Homework Presentation (Including Preparation Time) Activity (Web Search, Library Work, Trip, Observation, Interview etc.) Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice) Internship
12. Week radiation, pregnancy, embriology Lecture; Question Answer

Problem Based Learning; Scenario Based Learning; Case Based Learning 		Homework Presentation (Including Preparation Time) Activity (Web Search, Library Work, Trip, Observation, Interview etc.) Internship
13. Week potential lethal demage Discussion

Storyline; Case Based Learning 		Homework Presentation (Including Preparation Time) Internship
14. Week protection Lecture; Problem Solving

Problem Based Learning; Case Based Learning 		Homework Presentation (Including Preparation Time) Activity (Web Search, Library Work, Trip, Observation, Interview etc.) Internship

Sources Used in This Course
Recommended Sources
Basic clinical radiobiology / edited by Michael C. Joiner and Albert J. Van der Kogel. Fifth edition. 2018

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3DK4
PY455555

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
. 14 2
Course Duration (Total weeks*Hours per week) 14 2
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
Quick Access Hızlı Erişim Genişlet
Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • Relations with Education Attainment Program Course Competencies
  • ECTS credits and course workload