Course Information

Course Title	Code	Semester	L+U Hour	Credits	ECTS
Toxicogenetic	55431023		3 + 0	3.0	9.0

Prerequisites

None

Language of Instruction	Turkish
Course Level	Graduate Degree
Course Type	Compulsory
Mode of delivery	Face-to-face teaching, interactive discussion, seminar
Course Coordinator
Instructors
Assistants
Goals	Learning of the genetic factors affecting the toxicity caused by chemical substances
Course Content	Mechanisms of genetic susceptibility in diseases that can be caused by all the chemicals that humans may be exposed, genetic biomarkers that can be used in the development of disease and exposure status, the role of molecular mechanisms in the development of toxicity
Learning Outcomes	1) Learning of the role of genetic factors in the development of toxicity. 2) Learning of toxicity development mechanisms. 3) Learning of of the importance of genetic differences in toxicology.

Week	Topics	Teaching and Learning Methods and Techniques	Study Materials
1. Week	General Toxicology	Lecture; Question Answer; Problem Solving; Discussion; Case Study Brainstorming; Opinion Pool; Colloquium Problem Based Learning; Case Based Learning	Homework
2. Week	Absorption, distribution and excretion of chemicals	Lecture Colloquium Case Based Learning	Homework
3. Week	Metabolism of chemicals	Lecture Colloquium Case Based Learning	Homework
4. Week	Phase I metabolic enzymes	Lecture Colloquium Problem Based Learning	Homework
5. Week	Phase II metabolic enzymes	Lecture; Question Answer Colloquium Case Based Learning	Homework
6. Week	Chemical transporters	Lecture; Question Answer Problem Based Learning	Homework
7. Week	Midterm examination	Lecture; Question Answer Colloquium Case Based Learning	Homework
8. Week	Toxicodynamic	Lecture Colloquium Case Based Learning	Homework
9. Week	Human genome	Lecture Colloquium Problem Based Learning	Homework
10. Week	Differences in human genome	Lecture; Question Answer Colloquium Case Based Learning	Homework
11. Week	Methods of analysis of genomic differences	Lecture; Question Answer Brainstorming; Colloquium Problem Based Learning	Homework
12. Week	Toxicological results of genomic differences	Question Answer Colloquium Problem Based Learning	Homework
13. Week	Toxicogenetic examination of naturally occurring carcinogens	Question Answer Colloquium Case Based Learning	Homework
14. Week	Toxicogenetic examination of synthetic carcinogens	Question Answer Colloquium Case Based Learning	Homework

Recommended Sources

Toxicogenomics: A Powerful Tool for Toxicity Assessment, Edited by S. C. Sahu 2008 John Wiley & Sons, Ltd., 2008 ISBN: 978-0-470-51823-6

Essential Concepts in Toxicogenomics, Donna L. Mendrick (Editor),‎ William B. Mattes (Editor), Humana Press, 2008.

*DK = Course's Contrubution.

	0	1	2	3	4	5
Level of contribution	None	Very Low	Low	Fair	High	Very High

Event	Quantity	Duration (Hour)	Total Workload (Hour)
Course Duration (Total weeks*Hours per week)	14	3	42
Work Hour outside Classroom (Preparation, strengthening)	14	4	56
Homework	14	2	28
Presentation (Including Preparation Time)	14	3	42
Practice (Teaching Practice, Music/Musical Instrument Practice , Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)	14	4	56
Midterm Exam	1	2	2
Time to prepare for Midterm Exam	7	4	28
Final Exam	1	2	2
Time to prepare for Final Exam	7	4	28
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course			30