Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
METABOLISM, METABOLITES AND ROLE IN DRUG DESIGN 34104065 0 + 0 3.0 3.0

Prerequisites None

Language of Instruction Turkish
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors
Assistants
Goals Metabolites which occurs once taken into the body and new drug design starting from these
Course Content Introduction to drug metabolism, Factors that effect metabolism, Metabolism pathways, Phase I reactions, Aromatic hydroxylation and its examples, Hydoxylation of benzylic molecules and its examples, Oxidation in aliphatic reactions and its examples, Epoxidation and its examples, N/O/S-dealkylation and their examples, N/S-oxidation and their examples, Dehalogenation and examples, Reduction and hydrolysis reactions and examples, Drug design according to metabolites
Learning Outcomes 1) Knows absorption, distribution and excretion characteristics of drug active substance in the body, gains information about drug development based on from possible metabolites and relationships between chemical structure and biotransformation.
2) The design, synthesis and analysis of pharmaceutical active ingredients, and evaluate the facts of their behavior in biological environment and possible solutions.
3) Applies studies on design, synthesis, structure elucidation and analysis of pharmaceutically active substances.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
Epoxidation and examples Lecture; Question Answer
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
Dehalogenation and examples Lecture; Question Answer
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
1. Week Introduction to drug metabolism (biotransformation) Lecture
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
2. Week Factors affecting metabolism Lecture
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
3. Week Metabolic pathways Lecture
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
4. Week Phase I reactions Lecture
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
5. Week Aromatic hydroxylation and examples Lecture
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
6. Week Benzylic hydroxylation and examples Lecture
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
7. Week Oxidation of aliphatic molecules and examples Lecture
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
8. Week Epoxidation and examples Lecture; Question Answer
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
9. Week N, O, S-dealkylation and examples Lecture; Question Answer
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
10. Week N, S-oxidation and examples Lecture; Question Answer
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
11. Week Dehalogenation and examples Lecture; Question Answer
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
12. Week Reduction, hydrolysis reaction, and examples Lecture; Question Answer
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
13. Week New drug design according to the occurring metabolites Lecture; Question Answer
Colloquium
Problem Based Learning 		Presentation (Including Preparation Time)
14. Week Final exam


Sources Used in This Course
Recommended Sources
Introduction to Drug Metabolism, Dr G Gordon Gibson, Paul Skett, Cengage Learning; 3Rev Ed edition, 2001.

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3
PY13000
PY23000
PY33000

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 3
Work Hour outside Classroom (Preparation, strengthening) 14 1
Homework 7 1
Presentation (Including Preparation Time) 10 1
Activity (Web Search, Library Work, Trip, Observation, Interview etc.) 6 1
Final Exam 1 1
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
Quick Access Hızlı Erişim Genişlet
Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • Relations with Education Attainment Program Course Competencies
  • ECTS credits and course workload