Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
DRUG RELEASE KINETICS (PRACTICE) 34204014 0 + 4 2.0 4.0

Prerequisites None

Language of Instruction Turkish
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery Pratically
Course Coordinator
Instructors
Assistants
Goals The evaluation of dissolution rate for optimum dosage desing, evaluation of in vitro-in vivo dissolution data, dissolution data for optimization of formulation studies, importance of dissolution data for bioavailability and biequivalance studies.
Course Content The importance of dissolution for pharmaceutical technology, dissolution metheds and evaluation of dissolution data.
Learning Outcomes 1) Studies of dissolution tests
2) Dissolution tests methods
3) The selection of appropriate dissolution media and test methods

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week The therminology of dissolution rate , intrinsic dissolution rate , solubility , etc. and the importance of dissolution rate Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
2. Week The release of active material from solid dossage forms using different dissolution test apparatus Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
3. Week The release of active material from solid dossage forms using different dissolution test apparatus Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
4. Week The release of active material from solid dossage forms using different dissolution test apparatus Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
5. Week The release of active material from solid dossage forms using different dissolution test apparatus Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
6. Week The release of active material from solid dossage forms using different dissolution test apparatus Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
7. Week The release of active material from solid dossage forms using different dissolution test apparatus Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
8. Week The release of active material from solid dossage forms using different dissolution test apparatus Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
9. Week The release of active material from solid dossage forms using different dissolution test apparatus Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
10. Week The release of active material from solid dossage forms using different dissolution test apparatus Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
11. Week Kinetically and statistically evaluation of data obtained from dissolution tests. Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
12. Week Kinetically and statistically evaluation of data obtained from dissolution tests. Lecture
Brainstorming
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
13. Week Presentation and discussion of results. Discussion
Brainstorming
Brain Based Learning 		Presentation (Including Preparation Time) Report (Including Preparation and presentation Time)
14. Week Presentation and discussion of results. Discussion
Brainstorming
Brain Based Learning 		Presentation (Including Preparation Time) Report (Including Preparation and presentation Time)
15. Week Homework presentation Discussion
Brainstorming
Brain Based Learning 		Homework Presentation (Including Preparation Time)
16. Week Final exam Question Answer
Brainstorming
Brain Based Learning

Sources Used in This Course
Recommended Sources
Hiquchi, Mechanism of sustained action medication:theoretical analysis of rate of release of drugs dispersed in solid matrices, J.Pharm. Sci 52 (12), 1145-1149.
J.C. Johnson, Sustained Release Medications, Marcel Dekker Inc, 1980
Joseph R. Robinson, Vincent H.L. Lee, Controlled Drug Delivery Fundamentals and Applications, Marcel Dekker Inc, 1987
Langerbucher, Parametric representation of dissolution rate curves by the RRSBW distribution, Pharm. Ind. 38, 472-477.
Michael J. Rathbone, Jonathan Hadgraft, Michael S. Roberts, Modified-Release Drug Delivery Technology, Marcel Dekker Inc, 2003
Nurten Kaynar, İlbeyi Ağabeyoğlu, Modern Terapötik Sistemler: İlaç Formülasyonunda Yeni Atılımlar, FABAD, 6, 107-113, 1981
Nurten Kaynar, İlbeyi Ağabeyoğlu, Sürekli Etkili Preparatlarda Doz Tasarımı, FABAD, 2, 115-126, 1987
Praveen Tyle, Drug Delivery Devices, Marcel Dekker Inc, 1988
R. Larger, N. Peppas, Chemical and physical structure of polymers as carriers or controlled release of bioactive agents, JMS-Rev. Macromol. Chem. Phys. 23, 61-126.
U.V. Banakar, Pharmaceutical Dissolution Testing, Marcel Dekker Inc, 1992

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 4
Work Hour outside Classroom (Preparation, strengthening) 5 2
Homework 1 10
Presentation (Including Preparation Time) 2 10
Report (Including Preparation and presentation Time) 2 2
Final Exam 1 1
Time to prepare for Final Exam 2 10
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
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Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • ECTS credits and course workload