Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
ADVANCED TOXICOLOGY 34335003 2 + 0 2.0 6.0

Prerequisites None

Language of Instruction Turkish
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors Binay CAN EKE
Assistants
Goals The entry routes of xenobiotics, the mechanisms playing major role in absorption, distribution and metabolism of xenobiotics. The effects of enzymes responsible from the activation of xenobiotics in toxicity and the basis of differences in individual responses
Course Content The entry routes of xenobiotics, the mechanisms playing major role in their toxicokinetics. The topicas related with the effects of enzymes responsible from the activation of xenobiotics in toxicity and the basis of differences in individual responses.
Learning Outcomes 1) "He/She enhances his/her toxicology knowledge about toxicology basics, mechanisms and practices. He/She makes contact between toxicology and the other disciplines such as pharmacology, biochemistry, genetics, biophysics and forensic science which are collaborator sciences of toxicology. "
2) "He/She can solve the problems related with his/her field with research methods. He/She assesses and uses the original information and technologies in the field of toxicology. He/She performs in vivo or in vitro toxicological researches which investigate the detrimental effects of various factors to the organism. "
3) She/He publishes scientific article in national and/or international peer-review about her/his field thereby she/he increases her/his knowledge.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week Xenobiotic applications to experimental animals in various ways Lecture
Opinion Pool
Case Based Learning
Homework
2. Week Preparation of subcellular fractions Question Answer
Opinion Pool
Project Based Learning
Homework Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
3. Week Preparation of subcellular fractions Lecture
Six Hats Thinking
Project Based Learning
Presentation (Including Preparation Time)
4. Week Determination of proteins Lecture
Brainstorming
Project Based Learning
Homework
5. Week Evaluation of protein assay results Lecture
Opinion Pool
Project Based Learning
Homework
6. Week Determination of CYP enzyme system member P450 Lecture
Six Hats Thinking
Project Based Learning
Homework Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
7. Week Determination of CYP enzyme system member NADPH-cytochrome P450 reductase Lecture
Six Hats Thinking
Project Based Learning
Homework
8. Week midterm exam Lecture
Station
Project Based Learning
Presentation (Including Preparation Time)
9. Week Determination of total heme and b5 Lecture
Panel
Scenario Based Learning
Homework
10. Week Determination of Type I and Type II Spectral chemicals Lecture
Brainstorming
Project Based Learning
Homework
11. Week Measurement of CYP1A1 enzyme activity Lecture
Six Hats Thinking
Project Based Learning
Homework
12. Week Evaluation of the measurement of enzyme activity Lecture
Brainstorming
Storyline
Homework
13. Week Measurement of CYP2E1 enzyme activity Question Answer
Opinion Pool
Project Based Learning
Homework
14. Week Evaluation of the measurement of enzyme activity Lecture
Speech Loop
Project Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)

Sources Used in This Course
Recommended Sources
Conference on variability and specificity in drug metabolism
Human Drug Metabolism

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3
PY15232
PY25000
PY35000
PY45000

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 2
Work Hour outside Classroom (Preparation, strengthening) 14 2
Homework 12 2
Quiz 2 2
Time to prepare for Quiz 14 2
Midterm Exam 1 2
Time to prepare for Midterm Exam 8 3
Final Exam 1 2
Time to prepare for Final Exam 14 2
2 2
2 2
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
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Course Information