Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
INTRODUCTION TO PHARMACEUTICAL CHEMISTRY PHM2008 4. Semester 2 + 0 2.0 3.0

Prerequisites None

Language of Instruction English
Course Level Bachelor's Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors Zeynep ALAGÖZ
Assistants Tuncagül ALTUNTAŞ DİNLENÇ
ZÜHAL KILIÇ KURT
Goals This course aims to teach drug groups by associating drug chemistry with the design, development, chemical structure and biological activity relationships, metabolism and pharmacokinetic properties of drugs.
Course Content In this course which is an introduction to Pharmaceutical Chemistry courses, the scope and purpose of Pharmaceutical Chemistry, drug discovery and development, pharmacokinetic properties of drugs such as absorption, solubility, pK, ionization, concepts of isosterism, bioisosterism, target, ligand and receptor, transport systems, chemical bonds, drug- target interactions, stereochemistry-biological activity relationship, computer-aided drug design, quantitative structure-activity relationships, molecular modeling methods, metabolism and prodrug topics are discussed. Also, nomenclature rules are given briefly. Antihistamine compounds and non-steroidal anti-inflammatory drugs, which are effective on the immune system, are given in this course.
Learning Outcomes 1) Recognizes the basic sciences about the drug.
2) Knows information about design, synthesis, analysis and pharmacokinetics of pharmaceutical products
3) Gives consulting about pharmaceutical teamwork, research and development
4) Follows developments in the field of information and technology in order to increase the effectiveness of pharmacy services.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week Pharmaceutical Chemistry Content, Purpose Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning; Storyline 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
2. Week Drug discovery and development Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
3. Week Pharmacokinetic Properties of Drugs (Absorption, solubility, pK, Ionization) Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
4. Week Concepts of isosterism, bioisosterism, Target, Ligand, Receptor, and Transport systems Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
5. Week Chemical Bonds Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
6. Week Drug-target interactions Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
7. Week Stereochemistry-Biological Activity Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
8. Week Midterm Exam Question Answer
Brainstorming
 Presentation (Including Preparation Time)
9. Week Computer-Aided Drug Design Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
10. Week Quantitative Structure-Activity Relationships and Molecular Modeling Methods Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
11. Week Metabolism and prodrug Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
12. Week Drug names and nomenclature rules Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
13. Week Antihistaminic Compounds Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
14. Week Non-Steroidal Anti-Inflammatory Drugs Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
15. Week Non-Steroidal Anti-Inflammatory Drugs Lecture; Question Answer; Problem Solving
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)

Sources Used in This Course
Recommended Sources
Burger's Medicinal Chemistry, Drug Discovery and Development 7th Edition, 8 Volume Set ISBN: 978-0-470-27815-4 September 2010
Farmasötik Kimya Ders Kitabı Cilt 1 (Medisinal Kimya), N. Ergenç, A. Gürsoy, Ö. Ateş, ISBN: 975-404-506-2, İstanbul Üniversitesi Basımevi, 1997.
Farmasötik ve Medisinal Kimya, Hacettepe Üniversitesi Yayınları, ISBN: 9789754914894, 2019.
Foye's Principles of Medicinal Chemistry, ISBN-10: 1496385020 ISBN-13: 978-1496385024, Edition: 8, LWW, Publication Date: August 29, 2019.
Kantitatif Yapı-Etki İlişkileri Analizleri (QSAR), E. Akı-Şener and İ. Yalçın, Ankara Üniversitesi Basımevi, 2003.
Pharmaceutical Chemistry, David G. Watson (Author), ISBN-10: 0443072329 ISBN-13: 978-0443072321, Edition: 1, Elsevier, Publication Date: February 18, 2011
The Organic Chemistry of Drug Design and Drug Action, R.B. Silverman and M.W. Holladay (Author), ISBN: 978-0-12-382030-3, Edition: 3, Academic Press, 2014.
Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry, ISBN-10: 0781779294 ISBN-13: 978-0781779296 Edition: Twelfth, North American Edition, Publication Date: March 2, 2010.

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3DK4
PY150000
PY250000
PY350000
PY450000
PY550000

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 15 2
Work Hour outside Classroom (Preparation, strengthening) 15 2
Midterm Exam 1 1
Time to prepare for Midterm Exam 1 10
Final Exam 1 1
Time to prepare for Final Exam 1 20
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
Quick Access Hızlı Erişim Genişlet
Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • Relations with Education Attainment Program Course Competencies
  • ECTS credits and course workload