Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
PHARMACEUTICAL CHEMISTRY II PHM3004 6. Semester 3 + 0 3.0 4.0

Prerequisites None

Language of Instruction English
Course Level Bachelor's Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors Zeynep ALAGÖZ
Assistants Tuncagül ALTUNTAŞ DİNLENÇ
Sibel SÜZEN
Goals Aim of this course is to give knowledge and skill on the concept of chemotherapy, synthesis and mechanisms of action of chemotherapeutic drugs. It has an educational purpose and content related to the subject, as well as diseases, the patient's drug therapy and drug awareness about the need to direct the patient.
Course Content In this course formula, nomenclature, general physicochemical properties, general synthetic pathways, metabolism, stability, general chemical analysis, structure-activity relationships of pharmaceutical active ingredients used in diagnosis and treatment of some diseases are given. Within this general topic, concepts of chemotherapy and related terms, chemotherapeutics, beta-lactamase inhibitors (penicillines, cephalosporines), amino acid antibiotics, polypeptidic antibiotics, macrolide antibiotics, aminoglycosides, tetracyclines, chloramphenicol, sulfonamides, quinolone derivatives and antituberculosis drugs, antilepra compounds, antifungal compounds, antiviral drugs, anticancer drugs, urinary system drugs, anthelmentic and antiprotozoal compounds are also taught.
Learning Outcomes 1) Knows about the mechanisms of action and classification of chemotherapeutic which is the main topic of pharmaceutical chemistry. Establishes a relationship between structure and biological activity of chemotherapeutic compounds. Knows design, synthesis, pharmacological activity and pharmacokinetic properties of beta-lactam antibiotics and beta-lactamase inhibitors, amino acid antibiotics, polypeptidic antibiotics, macrolide antibiotics, aminoglycosides, tetracyclines, chloramphenicol, sulfonamides, and antituberculosis drugs, quinolone derivatives, and other antibiotics, antifungal compounds, and antiviral drugs.
2) It has ability to design and synthesis of chemotherapeutic effective drugs and reviews pharmacological effects from their molecular structure.
3) Informs the patient about the chemotherapeutic drugs
4) It has the ability to conduct research and development (R & D) studies on chemotherapeutic drugs

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
Anthelmentic and Antiprotozoal compounds Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
1. Week Concepts of chemotherapy and related terms, Mechanisms of chemotherapeutics Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
2. Week Sulfonamides and chloramphenicol Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
3. Week Tetracyclines Aminoglycosides Oxazolidinones Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
4. Week Aminoglycosides Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
5. Week Macrolides and Lincosamides Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
6. Week Antitubercular and Antilepra Compounds Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
7. Week Urinary system drugs Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
8. Week Midterm Exam Question Answer

 Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
9. Week Antifungal compounds Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
10. Week Antiviral Compounds Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
11. Week Anticancer drugs Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
12. Week Anticancer drugs Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
13. Week Penicillines Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
14. Week Cephalosporines Lecture; Question Answer
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)

Sources Used in This Course
Recommended Sources
Burger's Medicinal Chemistry, Drug Discovery and Development 7th Edition, 8 Volume Set ISBN: 978-0-470-27815-4 September 2010
Farmasötik Kimya Hacettepe Üniversitesi Yayınları ISBN: 978-975-491-171-8 3. Baskı, Aralık 2013
Foye's Principles of Medicinal Chemistry Publication Date: March 8, 2012 ISBN-10: 1609133455 ISBN-13: 978-1609133450 Edition: Seventh, North American Edition
Pharmaceutical Chemistry, David G. Watson (Author) Publication Date: February 18, 2011 ISBN-10: 0443072329 ISBN-13: 978-0443072321 Edition: 1
Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry Publication Date: March 2, 2010 ISBN-10: 0781779294 ISBN-13: 978-0781779296 Edition: Twelfth, North American Edition

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3DK4
PY150050
PY254404
PY350000
PY450000
PY550000

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 3
Work Hour outside Classroom (Preparation, strengthening) 14 3
Homework 2 4
Presentation (Including Preparation Time) 2 4
Project (Including Preparation and presentation Time) 5 2
Final Exam 1 1
Time to prepare for Final Exam 1 1
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
Quick Access Hızlı Erişim Genişlet
Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • Relations with Education Attainment Program Course Competencies
  • ECTS credits and course workload