Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
PHARMACEUTICAL CHEMISTRY PRACTICE II PHM388 6. Semester 0 + 4 2.0 3.0

Prerequisites None

Language of Instruction English
Course Level Bachelor's Degree
Course Type Compulsory
Mode of delivery .
Course Coordinator
Instructors Zeynep ALAGÖZ
Assistants Tuncagül ALTUNTAŞ DİNLENÇ
Meltem CEYLAN ÜNLÜSOY
Sibel SÜZEN
Goals Aim of this course is to consider the chemical structure and functional groups of the active drugs, selection of the starting materials used in the synthesis of intermediate products and pharmaceutical active compounds and in order to achieve the desired product to gain theoretical and practical knowledge on the applicability of the methods of organic synthesis.
Course Content In this course synthesis of a variety of pharmaceutical active ingredients (Iodoform, benzyl alcohol, benzoic acid, p-nitro acetanilide), hydrolysis of aspirin, benzocaine, benzoin, benzyl, benzylic acid synthetic methods are given. The course curriculum also covers the synthesis of compounds such as benzylidene aniline, phenyl azo beta naphthol, ethyl acetate, acetanilide, dibenzalacetone, benzyl phenoxime, diazoaminobenzene.
Learning Outcomes 1) Knows how to achieve chemical structures by evaluating functional groups contained in the active pharmaceutical ingredients.
2) Knows the methods of organic synthesis and how to synthesized a variety of pharmaceutical active ingredients and / or intermediate step products are in theoretical and practical level
3) Sets out which of the starting materials and organic synthesis methods can be used in the synthesis of pharmaceutical active ingredients.
4) Takes a role in phase synthesis of organic compounds and pharmaceutical active ingredients include research and development activities, professional development continues

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week Introduction to organic reactions, classification of organic synthesis reactions, substitution, elimination and addition reactions Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
2. Week Nitration of aromatic compounds, synthesis of ester and amide functional groups, hydrolysis reactions Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
3. Week Nucleophilic addition reactions, Condensation reactions Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
4. Week Oxidation and reduction reactions, calculation of the yield of organic synthesis reactions Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
5. Week Synthesis of benzyl Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
6. Week Synthesis of benzoin Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
7. Week Synthesis of p-nitro acetanilide Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
8. Week Hydrolysis of Aspirin Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
9. Week Synthesis of Benzylic Acid Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
10. Week Synthesis of benzocaine Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
11. Week Synthesis of Iodoform Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
12. Week Cannizaro reaction, synthesis of benzyl alcohol and benzoic acid Lecture
Colloquium
Problem Based Learning 		Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
13. Week Synthesis of a variety of pharmaceutical active ingredients and/or intermediate step products Lecture
Colloquium
Problem Based Learning 		Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)
14. Week Midterm exam Question Answer

 Practice (Teaching Practice, Music/Musical Instrument Practice, Statistics, Laboratory, Field Work, Clinic and Polyclinic Practice)

Sources Used in This Course
Recommended Sources
Ankara Üniversitesi Eczacılık Fakültesi Farmasötik Kimya Pratikleri 1-2 ISBN: 975-482-649-8 Ankara Üniversitesi Basımevi, 2004
Denel Organik Kimya, Ender Erdik, Ankara Üniversitesi Yayınları
İlaçların Tanınması ve Kantitatif Tayini Prof. Dr. Nedime Ergenç, Prof. Dr. Aysel Gürsoy, Prof. Dr. Öznur Ateş İstanbul Üniversitesi Yayınları (No: 3566) 4. Baskı, 1989 ISBN: 975-404-124-5
Organik Kimya, Graham Solomon, Craig Fryhle, Literatür Yayıncılık
Synthesis of Essential Drugs, Ruben Vardanyan, Victor Hruby, Elsevier

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3DK4
PY150000
PY250000
PY350000
PY450000
PY550000

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 3
Work Hour outside Classroom (Preparation, strengthening) 14 2
Report (Including Preparation and presentation Time) 7 2
Midterm Exam 1 1
Final Exam 1 1
Time to prepare for Final Exam 1 10
1 1
1 1
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
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Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • Relations with Education Attainment Program Course Competencies
  • ECTS credits and course workload