Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
PHARMACEUTICAL CHEMISTRY IV PHM4004 8. Semester 2 + 0 2.0 3.0

Prerequisites None

Language of Instruction English
Course Level Bachelor's Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors Ali Hakan GÖKER
Assistants
Goals Aim of this course is to develop knowledge and skills on the synthesis and mechanisms of action of drugs used in gastrointestinal tract, respiratory system and endocrine system diseases drugs. Besides examining the diseases about subject, the purpose and content of this education will allow students as persons who can inform and guide patients about drugs in the treatment with medicines.
Course Content In this course formula, nomenclature, general physicochemical properties, general synthetic pathways, metabolism, stability, general chemical analysis, structure-activity relationships and therapeutic uses of drugs acting on the digestive system, medications used in ulcer treatment, laxatives, purgatives, antidiarrheal compounds, emetics, anti-emetics, radiodiagnostic drugs, mucolytics, expectorants, antitussives, oral antidiabetics, antihypoglycemics, hormones, steroid hormones, thyroid hormones, thyroid active compounds and antithyroid compounds are taught.
Learning Outcomes 1) Designs and synthesises medicines that are effective in endocrine system, digestive system and respiratory system, inteprets the pharmacological effects of molecular structure
2) Informs patients about the endocrine system, the digestive system and the respiratory system related drugs
3) Conducts pharmaceutical research and development (AR-GE) studies related to endocrine system, digestive system and respiratory system.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week General Introduction - Definitions (definition of endocrine system and hormones). The basic functions of hormones, developments on neurohormones and stem cell, classification of hormones and their basic functions, general synthesis methods of hormones, endocrine disorders and basic approaches in treatment, hypothalamic hormones, hormones released from the pituitary gland, gonadotropin hormones, neurohypophysis, hormones Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
2. Week Steroid hormones and their chemical structures, adrenal cortex hormones, ovarian ((female sex) hormones, estrogenic hormones, estrogens with various characteristics, conjugated estrogens, nonsteroidal estrogens Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
3. Week Gestagenic hormones, Contraception and 19-nor steroids, androgen hormones, Efects of androgens non sexuel specific Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
4. Week Anabolics and doping, androstane group anabolics, testosterone anabolics, Thyroid Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
5. Week Pancreatic hormones-insulin, general information about glucagon, oral antidiabetics Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
6. Week Oral antidiabetics, enzyme inhibitors, antihypoglycemics Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
7. Week General information about the respiratory system, mucolytics Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
8. Week Expectorants, antitussives Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
9. Week Midterm Exam Question Answer

10. Week Drugs acting on the digestive system, digestive system enzymes Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
11. Week Medications used in ulcer treatment - Antacids - Drugs that reduce acid secretion - Histamine H2-receptor blockers Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
12. Week Medications used in ulcer treatment - Proton pump-inhibiting drugs - Antimuscarinic drugs - Protective film-forming drugs Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
13. Week Emetic and antiemetics -Laxatives and purgatives Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)
14. Week Prokinetic compounds -Antidiarrheal compounds Lecture; Question Answer
Colloquium
Problem Based Learning
Activity (Web Search, Library Work, Trip, Observation, Interview etc.)

Sources Used in This Course
Recommended Sources
Burger's Medicinal Chemistry, Drug Discovery and Development 7th Edition, 8 Volume Set ISBN: 978-0-470-27815-4 September 2010
Farmasötik Kimya Hacettepe Üniversitesi Yayınları ISBN: 978-975-491-171-8 3. Baskı, Aralık 2013
Foye's Principles of Medicinal Chemistry Publication Date: March 8, 2012 ISBN-10: 1609133455 ISBN-13: 978-1609133450 Edition: Seventh, North American Edition
Pharmaceutical Chemistry, David G. Watson (Author) Publication Date: February 18, 2011 ISBN-10: 0443072329 ISBN-13: 978-0443072321 Edition: 1
Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry Publication Date: March 2, 2010 ISBN-10: 0781779294 ISBN-13: 978-0781779296 Edition: Twelfth, North American Edition

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3
PY15000
PY25444
PY35000
PY45000
PY55000

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 2
Work Hour outside Classroom (Preparation, strengthening) 14 1
Midterm Exam 1 1
Time to prepare for Midterm Exam 1 15
Final Exam 1 1
Time to prepare for Final Exam 1 20
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
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Course Information