Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
SELECTIVE TOXICITY ATO5602013 3 + 0 3.0 6.0

Prerequisites None

Language of Instruction Turkish
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors
Assistants
Goals To give information about the principles of selective toxicity and its importance in drug development.
Course Content There are topics that provide information about the principles of selective toxicity and its importance in drug development.
Learning Outcomes 1) Explains the mechanisms of selective toxicity.
2) Explain the differences in biotransformation mechanism.
3) Explain the importance of selectivity in drug development.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week Introduction to selective toxicity Selective toxicity mechanisms Chemical principles of selectivity Differences in cell structure Differences in the mechanism of distribution Differences in the biotransformation mechanism Enzyme and receptor systems in selectivity Enzyme and receptor systems in selectivity Covalent bonds in selective toxicity Metabolite and metabolite analogues in selective toxicity Selectivity in biological systems Letal synthesis The importance of selectivity in drug development Case studies Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
2. Week Selective toxicity mechanisms Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
3. Week Chemical principles of selectivity Lecture; Question Answer

Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
4. Week Differences in cell structure Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
5. Week Differences in the mechanism of distribution Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
6. Week Differences in the biotransformation mechanism Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
7. Week Enzyme and receptor systems in selectivity Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
8. Week Enzyme and receptor systems in selectivity Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
9. Week Covalent bonds in selective toxicity Lecture; Question Answer
Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
10. Week Metabolite and metabolite analogues in selective toxicity Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
11. Week Selectivity in biological systems Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
12. Week Letal synthesis Lecture; Question Answer
Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
13. Week The importance of selectivity in drug development Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)
14. Week Case studies Lecture; Question Answer
Brainstorming; Opinion Pool
Scenario Based Learning; Brain Based Learning 		Homework Presentation (Including Preparation Time)

Sources Used in This Course
Recommended Sources
Casarett&Doull’s Toxicology: The Basic Science of Poisons.
Selective Toxicity, The Physico-chemical basis of therapy.

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3
PY45555
PY55555
PY65555
PY75555
PY85555
PY95555
PY105444

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 3
Work Hour outside Classroom (Preparation, strengthening) 14 2
Homework 1 14
Presentation (Including Preparation Time) 14 2
Seminar 1 1
Midterm Exam 1 2
Time to prepare for Midterm Exam 7 2
Final Exam 1 2
Time to prepare for Final Exam 14 4
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
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Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • Relations with Education Attainment Program Course Competencies
  • ECTS credits and course workload