Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
DRUG RELEASE KINETICS 34233013 2 + 0 2.0 4.0

Prerequisites None

Language of Instruction Turkish
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors
Assistants
Goals It includes the design, formulation and evaluation of dosage forms that provide the ideal treatment by keeping the blood level at the therapeutic level for the desired period of time, taking less doses instead of conventional dosage forms. It also studies the targeting of the active substance for controlled release.
Course Content ontrolled release terminology, precaution. Dose design in controlled release systems. Mechanism of drug release from controlled release systems. Technological approaches in the preparation of controlled release systems. Drug targeting, targeting mechanisms and prevention.
Learning Outcomes 1) Mechanism of drug release from controlled release dosage forms.
2) Diffusion-controlled, partition-controlled, chemically controlled, osmotically controlled systems and their kinetic studies
3) Drug targeting mechanisms
4) Controlled release dosage forms and technological production methods
5) Targeting with monoclonal antibodies and erythrocytes.
6) Dose design in controlled release systems.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week Controlled release terminology, precaution. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
2. Week Controlled release terminology, precaution. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
3. Week Dose design in controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
4. Week Dose design in controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
5. Week Mechanism of release of active substance from controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
6. Week Mechanism of release of active substance from controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
7. Week Midterm exam Question Answer
8. Week Mechanism of release of active substance from controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
9. Week Mechanism of release of active substance from controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
10. Week Technological approaches in the preparation of controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
11. Week Technological approaches in the preparation of controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
12. Week Drug targeting, targeting mechanisms and precaution. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
13. Week Drug targeting, targeting mechanisms and precaution. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
14. Week Drug targeting, targeting mechanisms and precaution. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
15. Week Drug targeting, targeting mechanisms and precaution. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
16. Week Final exam Question Answer

Sources Used in This Course
Recommended Sources
1 Praveen Tyle, Drug Delivery Devices, Marcel Dekker Inc, 1988 2 J.C. Johnson, Sustained Release Medications, Marcel Dekker Inc, 1980 3 U.V. Banakar, Pharmaceutical Dissolution Testing, Marcel Dekker Inc, 1992 4 Michael J. Rathbone, Jonathan Hadgraft, Michael S. Roberts, Modified-Release Drug Delivery Technology, Marcel Dekker Inc, 2003 5 Langerbucher, Parametric representation of dissolution rate curves by the RRSBW distribution, Pharm. Ind. 38, 472-477. 6 Nurten Kaynar, İlbeyi Ağabeyoğlu, Sürekli Etkili Preparatlarda Doz Tasarımı, FABAD, 2, 115-126, 1987 7 Nurten Kaynar, İlbeyi Ağabeyoğlu, Modern Terapötik Sistemler: İlaç Formülasyonunda Yeni Atılımlar, FABAD, 6, 107-113, 1981 8 R. Larger, N. Peppas, Chemical and physical structure of polymers as carriers or controlled release of bioactive agents, JMS-Rev. Macromol. Chem. Phys. 23, 61-126. 9 Joseph R. Robinson, Vincent H.L. Lee, Controlled Drug Delivery Fundamentals and Applications, Marcel Dekker Inc, 1987 10 Hiquchi, Mechanism of sustained action medication:theoretical analysis of rate of release of drugs dispersed in solid matrices, J.Pharm. Sci 52 (12), 1145-1149. 1 Praveen Tyle, Drug Delivery Devices, Marcel Dekker Inc, 1988 2 J.C. Johnson, Sustained Release Medications, Marcel Dekker Inc, 1980 3 U.V. Banakar, Pharmaceutical Dissolution Testing, Marcel Dekker Inc, 1992 4 Michael J. Rathbone, Jonathan Hadgraft, Michael S. Roberts, Modified-Release Drug Delivery Technology, Marcel Dekker Inc, 2003 5 Langerbucher, Parametric representation of dissolution rate curves by the RRSBW distribution, Pharm. Ind. 38, 472-477. 6 Nurten Kaynar, İlbeyi Ağabeyoğlu, Sürekli Etkili Preparatlarda Doz Tasarımı, FABAD, 2, 115-126, 1987 7 Nurten Kaynar, İlbeyi Ağabeyoğlu, Modern Terapötik Sistemler: İlaç Formülasyonunda Yeni Atılımlar, FABAD, 6, 107-113, 1981 8 R. Larger, N. Peppas, Chemical and physical structure of polymers as carriers or controlled release of bioactive agents, JMS-Rev. Macromol. Chem. Phys. 23, 61-126. 9 Joseph R. Robinson, Vincent H.L. Lee, Controlled Drug Delivery Fundamentals and Applications, Marcel Dekker Inc, 1987 10 Hiquchi, Mechanism of sustained action medication:theoretical analysis of rate of release of drugs dispersed in solid matrices, J.Pharm. Sci 52 (12), 1145-1149.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 2
Work Hour outside Classroom (Preparation, strengthening) 14 5
Midterm Exam 1 2
Time to prepare for Midterm Exam 1 15
Final Exam 1 2
Time to prepare for Final Exam 1 15
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
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Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • ECTS credits and course workload