Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
POLYMERS USED IN CONTROLLED RELEASE OF DRUGS (PRACTICE) 34234048 0 + 4 2.0 4.0

Prerequisites None

Language of Instruction Turkish
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery Lecture, question and answer, discussion
Course Coordinator
Instructors
Assistants
Goals In systems that release controlled active substances, both natural and synthetic to control the release of active substance polymers are used. This derste briefly describes the definitions of polymers, polymer types, their properties and the mechanism of active substance release; controlled to be used in the preparation of dosage forms releasing active substance the proper selection of the polymers and the quality of the polymeric systems control information.
Course Content Polymer science, definitions Polymerization methods Properties of polymers Thermal properties of polymers Polymer solutions Diffusion from polymers Polymers used in controlled release systems Classification of polymers Biodegradable polymers Biodegradable polymers Mechanisms of active substance release from biodegradable polymers hydrogels Mechanisms of active substance release from hydrogels Water soluble polymers
Learning Outcomes 1) Know the preparation of polymeric active substance release systems (microspheres, matrix type preparations)
2) Know the polymer selection and formulation for the targeted release of active substance
3) Effect of polymer type on controlled release of active substance
4) It is possible to determine the mode and rate of release of active substance from prepared polymeric systems
5) Know the quality control of polymeric drug delivery systems

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week Polymer selection Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
2. Week Preparation of solutions of polymers Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
3. Week Measurement of viscosities of solutions of polymers Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
4. Week Determination of thermal properties of polymers Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
5. Week Establishment of the method of active substance identification and quantification Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
6. Week Establishment of the method of active substance identification and quantification Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
7. Week Preparation of control-releasing preparations with polymers (such as microparticles, nanoparticles, matrix tablets) Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
8. Week Evaluation of the effect of polymer type and amount on the formation of preparations Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
9. Week Investigation of the effects of polymers on active matter loading Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
10. Week Determination of the effect of polymers on processing yield Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
11. Week Examination of the release and mechanism of active substance from polymers Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
12. Week To investigate the release and mechanism of active substances of polymers Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
13. Week Investigation of polymer active substance interactions Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
14. Week Investigation of polymer active substance interactions Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
15. Week homework presentation Lecture; Question Answer; Discussion
Brainstorming
Problem Based Learning 		Homework Presentation (Including Preparation Time) Report (Including Preparation and presentation Time)
16. Week Final exam Question Answer

Sources Used in This Course
Recommended Sources
"Joseph R. Robinson and Vincent H.L. Lee, Controlled Drug Delivery - Fundamentals and Applications, Marcel Dekker, Inc., 1987. " Alfred Martin, Pilar Bustamante and A.H.C. Chun, Physical Pharmacy, Lea&Febiger, 1993. Tom Sam and Jasper Fokkens (Eds.), Innovations in Drug Delivery: Impact on Pharmacotherapy, CIP-gegevens Koninklijke Bibliotheek, 1996. Ayla Gürsoy, Erhan Pişkin, Betül A. Dortunç and Nicholas A. Peppas, Kontrollu İlaç Serbestleştiren Sistemler, Tekno Grafik&Ada Ofset,1989. Ayla Gürsoy (Ed.), Kontrollu Salım Sistemleri, Elma Bilgisayar BasımAmbalaj San. Tic. Ltd. Şti., 2002. Waleed S.W. Shalaby and Haesun Park, Biodegradable Hydrogels for Drug Delivery, Technomic Publishing Company, Inc.,1993. Nilüfer Yüksel,Teoman Tinçer and Tamer Baykara, The interaction between Nicardipine hydrochloride and polymeric microspheres for a controlled release system, Int. J.Pharm., 1996.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 15 2
Work Hour outside Classroom (Preparation, strengthening) 15 4
Homework 1 1
Presentation (Including Preparation Time) 1 10
Report (Including Preparation and presentation Time) 1 10
Final Exam 1 1
Time to prepare for Final Exam 1 10
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
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Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • ECTS credits and course workload