Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
DISSOLUTION RATE ANALYSIS AND DATA EVALUATION 34233019 2 + 0 2.0 4.0

Prerequisites None

Language of Instruction Turkish
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors Burcu DEVRİM GÖKBERK
Assistants
Goals It includes the design, formulation and evaluation of dosage forms that provide the ideal treatment by keeping the blood level at the therapeutic level for the desired period of time, taking less doses instead of conventional dosage forms. It also studies the targeting of the active substance for controlled release.
Course Content ontrolled release terminology, precaution. Dose design in controlled release systems. Mechanism of drug release from controlled release systems. Technological approaches in the preparation of controlled release systems. Drug targeting, targeting mechanisms and prevention.
Learning Outcomes 1) Mechanism of drug release from controlled release dosage forms.
2) Diffusion-controlled, partition-controlled, chemically controlled, osmotically controlled systems and their kinetic studies
3) drug targeting mechanisms
4) Controlled release dosage forms and technological production methods
5) Targeting with monoclonal antibodies and erythrocytes.
6) Dose design in controlled release systems.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week terminology and importance of controlled release Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
2. Week terminology and importance of controlled release Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
3. Week ,Dose design in controlled release systems Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
4. Week ,Dose design in controlled release systems Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
5. Week Mechanism of release of active substance from controlled release systems. Lecture
Brainstorming
 Presentation (Including Preparation Time)
6. Week Mechanism of release of active substance from controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
7. Week mid-term exam Question Answer
8. Week Mechanism of release of active substance from controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
9. Week Mechanism of release of active substance from controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
10. Week Technological approaches in the preparation of controlled release systems.ches in the preparation of controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
11. Week Technological approaches in the preparation of controlled release systems.ches in the preparation of controlled release systems. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
12. Week Drug targeting, targeting mechanisms and precaution. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
13. Week Drug targeting, targeting mechanisms and precaution. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)
14. Week Drug targeting, targeting mechanisms and precaution. Lecture
Brainstorming
Problem Based Learning 		Presentation (Including Preparation Time)

Sources Used in This Course
Recommended Sources
U.V. Banakar, Pharmaceutical Dissolution Testing, Marcel Dekker Inc, 1992
Hiquchi, Mechanism of sustained action medication:theoretical analysis of rate of release of drugs dispersed in solid matrices, J.Pharm. Sci 52 (12), 1145-1149.
J.C. Johnson, Sustained Release Medications, Marcel Dekker Inc, 1980
Michael J. Rathbone, Jonathan Hadgraft, Michael S. Roberts, Modified-Release Drug Delivery Technology, Marcel Dekker Inc, 2003
Nurten Kaynar, İlbeyi Ağabeyoğlu, Sürekli Etkili Preparatlarda Doz Tasarımı, FABAD, 2, 115-126, 1987
Joseph R. Robinson, Vincent H.L. Lee, Controlled Drug Delivery Fundamentals and Applications, Marcel Dekker Inc, 1987
Langerbucher, Parametric representation of dissolution rate curves by the RRSBW distribution, Pharm. Ind. 38, 472-477.
Nurten Kaynar, İlbeyi Ağabeyoğlu, Modern Terapötik Sistemler: İlaç Formülasyonunda Yeni Atılımlar, FABAD, 6, 107-113, 1981
Praveen Tyle, Drug Delivery Devices, Marcel Dekker Inc, 1988
R. Larger, N. Peppas, Chemical and physical structure of polymers as carriers or controlled release of bioactive agents, JMS-Rev. Macromol. Chem. Phys. 23, 61-126.

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3DK4DK5DK6
PY15000000
PY25000000
PY35000500
PY45000500
PY55000000

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 2
Work Hour outside Classroom (Preparation, strengthening) 14 5
Midterm Exam 1 2
Time to prepare for Midterm Exam 1 15
Final Exam 1 2
Time to prepare for Final Exam 1 15
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
Quick Access Hızlı Erişim Genişlet
Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • Relations with Education Attainment Program Course Competencies
  • ECTS credits and course workload