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Language of Instruction
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Turkish
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Course Level
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Graduate Degree
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Course Type
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Compulsory
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Mode of delivery
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Course Coordinator
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Instructors
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Emel
EMREGÜL
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Assistants
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Goals
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Genes and chromosomes, chromosomal elements, size of DNA and DNA sequence structure, DNA superfolding, chromatin and nucleotide structure, tertiary structure of DNA in chromosomes, viral and cellular chromosomal elements, DNA topology, protein-DNA interactions, DNA metabolism, DNA mapping, DNA repair, E.coli repair repair systems, DNA recombination, Recombination enzymes, Region specific recombination, Transposons, Recombination of immunoglobulin genes, RNA metabolism, DNA-dependent RNA synthesis, RNA synthesis in promoters, RNA processing, rRNA and tRNA processing, Ribozymes, Cellular mRNA fragmentation, RNA dependent DNA and RNA synthesis, RNA replicases, Many transposon, retrovirus and common evolutionary origins of introns, replication of telomeres, protein metabolism, genetic code, protein synthesis, Wobble hypothesis, protein targeting, and fragmentation, post-transformational modifications of many eukaryotic proteins, regulation of gene expression in prokaryotes and eukaryotes
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Course Content
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Gene and chromosomes, chromosomal elements, Length of DNAand The structure of DNA squences, DNA supercoiling , The structure of choromatin and nucleotide, Tertiary sturucture of DNA packaged in chromosoms, Viral and cellular chromosomal elements, DNA topology, Protein-DNA interactions, DNA metabolism, DNA replication,DNA repair, Types of DNA repair systems in E.coli, DNA recombination, Recombination enzymes, Site specific recombination,Transposons, Recombination of immunoglobulin genes, RNA metabolism, DNA dependent synthesis of RNA, Initiation of RNA at promotors, RNA processing, rRNA and tRNA proscessing, Ribozymes, Degradation of cellular mRNAs, RNA dependent synthesisof RNA and DNA, RNA replicase.Common evolutionary origin of many transposons,retroviruses and introns, Replication of Telomers, Protein metabolism, The genetic code, Protein synthesis, Wobble Hypothesis, Protein targeting and degrdegradation, Posttransyonal modificationsof many eucaryotic proteins, Gene expression. Regulation of gene expression in prokaryotes and eukaryotes.
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Learning Outcomes
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1)
Knows the chromosomal elements and explains the levels of organization that provides the tightening of DNA
2)
Summarize the process of self-matching of DNA and understand the importance of the enzymes used. Compares the DNA repair mechanisms with each other. Knows the importance of recombination and explains its function. Make comments about the importance of recombination, which constitutes antibody diversity.
3)
Explain RNA synthesis and explain the differences and common characteristics between DNA and RNA synthesis. mRNA knows the vital importance of intercepting the introns that have been written or described and explains the formation of mature mRNA.
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