Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
STEREOCHEMISTRY II 801300715620 3 + 0 3.0 8.0

Prerequisites None

Language of Instruction Turkish
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery Theoretical lecture
Course Coordinator
Instructors
Assistants
Goals To give knowledge about optic isomery, structural identification, resolution and physical and chemical properties of optic isomers, and principles of asymmetric synthesis.
Course Content Optical isomerism based on asymmetrical carbon atom (chirality), optical rotation degree, configuration, enantiomers and racemates, isomers with more than one asymmetrical carbon atom, diastereomers, anomers and mutarotation, asymmetric convertion, asymmetric synthesis, configurational correlation, chirality resulting from restricted rotation (atropisomerism).
Learning Outcomes 1) Recognize the stereochemical terms and concepts, and explain with examples.
2) Depict and explain the probable racemization mechanisms of chiral compounds.
3) Interpret the types and properties of racemic mixtures.
4) To make suggestions to the suitable separation methods for the racemic mixture.
5) Predict and depict the proper mechanism, and stereochemical outcome for a given reaction.
6) Propose and explain the reaction conditions and mechanisms for synthesis of a given stereomer.
7) Apply the knowledge and skills gained during the course to solving problems.
8) Review the literatüre and write a report on a given subject relevant to stereochemistry.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week Chiral compounds, and polarized light; optical activity; specific optical rotation angle; optical purity. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
2. Week Structures and optical properties of compounds with a chiral center. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
3. Week Stereochemistry of molecules with more than one chiral center. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
4. Week Streochemistry of chiral compounds with stereogenic centers other than carbon atom. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
5. Week Racemic mixture and its properties. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
6. Week Racemization, mutarotation, and epimerization reactions. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
7. Week Separation methods of enantiomers: mechanical separation, via diastereomers, and chiral chromatography, kinetic, and biochemical resolution. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
8. Week Stereoisomerism due to restricted rotation; axial chirality; biaryls, and triayls. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
9. Week Chiral spiranes, alkylidenecycloalkanes, catenanes, and helical structures. Question Answer; Discussion

 Presentation (Including Preparation Time)
10. Week Stereochemical aspects of stereoselective reactions; stereochemical rules and models. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
11. Week Enantioselective reaction mechanisms, and stereochemistry of the products occurred. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
12. Week Examples for diastreoselective reactions and mechanisms. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
13. Week Experimental determination of configuration of a chiral molecule. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)
14. Week Molecular recognition, natural and synthetic receptors, chiral molecular devices and machines; importance and applications. Lecture; Question Answer; Discussion

 Presentation (Including Preparation Time)

Sources Used in This Course
Recommended Sources
Nasipuri, D. Organik Bileşiklerin Stereokimyası; prensipleri ve uygulamaları, 1994, New Age Int. Ltd, New Delhi.
Tüzün C. “Stereokimya Ders Notları”

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3DK4DK5DK6DK7DK8
PY1500000000
PY2500000000
PY3500000000
PY4500000000
PY5500000000

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 3
Work Hour outside Classroom (Preparation, strengthening) 14 3
Homework 3 3
Report (Including Preparation and presentation Time) 1 32
Activity (Web Search, Library Work, Trip, Observation, Interview etc.) 2 5
Midterm Exam 2 2
Time to prepare for Midterm Exam 1 24
Final Exam 1 3
Time to prepare for Final Exam 1 32
1 2
1 2
1 32
1 3
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
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Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • Relations with Education Attainment Program Course Competencies
  • ECTS credits and course workload