Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
BIOCHEMISTRY II KİM0320 4 + 0 0 4.0

Prerequisites None

Language of Instruction Turkish
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors
Assistants
Goals To give comprehensive information regarding the metabolism of biomolecules (carbohydrates, lipids, proteins, nucleic acids and vitamins), the electron transport system and oxidative phosphorylation.
Course Content Metabolisms of biomolecules (carbohydrates, lipids, proteins, nucleic acids and vitamins), electron transport system and oxidative phosphorylation.
Learning Outcomes 1) Compares different cell types, presents cellular location and functions of the organels.
2) Discusses the organic and inorganic molecules, and their mechanisms uptaken or expelled by the cells.
3) Understands that the chemical reactions in the organism are realized on the basis of thermodynamic laws. Predicts in advance if a reaction will be spontaneously realized or not under the organism conditions.
4) Indicates the composition, body uptake, cellular synthetic and catabolic reactions of carbohydrates, lipids, proteins, nucleotides and vitamins, and indicates their importance to the organism.
5) Orders the oxidative phosphorylation steps, and compares the factors effecting oxidative phosphorylation organization.
6) Describes the concepts regarding the photosynthesis topic. Explains the light-dependent and light-independent reactions of photosynthesis, and ATP synthesis in the plants.
7) Knows DNA packaging and compares DNA transcription.
8) Expresses protein biosynthesis.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week Structure of the Cell and Transport from the Cell Membrane Lecture; Question Answer; Discussion
Brainstorming; Colloquium
Problem Based Learning 		Homework
2. Week Structure of the Cell and Transport from the Cell Membrane Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
3. Week Introduction to Metabolism: Hydrolysis, condensation, phosphate transport, oxidoreduction reactions, introduction to metabolism, catabolism, anabolism, autotrophic organisms, heterotrophic organisms, biochemical reactions, organization of the metabolism, reaction types of biochemical significance, thermodynamic properties of substances, energy, enthalpy, entropy, free energy, laws of thermodynamics, standard free energy change, high energy compounds. Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
4. Week Carbohydrate Metabolism:Glycolysis, pentose phospate Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
5. Week Carbohydrate Metabolism:Krebs Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
6. Week Biological Oxidation: Oxidative phosphorylation, mitochondrion, NAD+ NADP+ linked dehydrogenases, flavin linked dehydrogenases, Fe-S centers, ubiquinone, cytochromes, ATP synthase, chemiosmotic theory, malate-aspartate shuttle, glycerol-3-phosphate shuttle, regulation of oxidative phosphorylation. Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
7. Week Photosynthesis: Photosynthetic organisms, photosynthesis in higher plants, Hill reaction, light absorption, phycobilisome, photosystem I, photosystem II, ATP synthesis, proton and electron cycle in thylakoids, photosynthetic carbohydrate synthesis, regulation of carbohydrate metabolism in plants, Calvin cycle, photorespiration. Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
8. Week Lipid Metabolism: beta oxidation,ketone bodies Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
9. Week Lipid Metabolism: Synthesis Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
10. Week Protein ve Amino Acid Metabolism:transamination Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
11. Week Protein ve Amino Acid Metabolism: ürea synthesis, nitrate Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
12. Week Nucleotide Metabolism: Components of nucleotides, nucleosides, nucleotides, functions of nucleotides, intake of nucleotides, purine ribonucleotide synthesis, AMP and GMP formation from IMP, de novo synthesis of pyrimidine nucleotides, degradation of purine nucleotides, degradation of pyrimidine nucleotides. Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
13. Week Nucleic Acid Metabolism: Functions of nucleic acids, DNA packaging, histones, semiconservative replication, DNA replication, DNA replication steps in E. coli, transcription, DNA transcription steps in E. coli, transcription in eukaryotic cells, RNA processing, translation, ribosomes, protein synthesis in prokaryotes. Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework
14. Week Nucleic Acid Metabolism: Functions of nucleic acids, DNA packaging, histones, semiconservative replication, DNA replication, DNA replication steps in E. coli, transcription, DNA transcription steps in E. coli, transcription in eukaryotic cells, RNA processing, translation, ribosomes, protein synthesis in prokaryotes. Lecture; Question Answer
Brainstorming; Colloquium
Problem Based Learning 		Homework

Sources Used in This Course
Recommended Sources
LEHNINGER-BİYOKİMYANIN İLKELERİ - Beşinci Baskıdan Çeviri, Çeviri Editörü: Elçin, Y.M., 1158 sayfa, ISBN 978-605-355-139-3, Palme Yayıncılık, Ankara, 2013.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 4
Work Hour outside Classroom (Preparation, strengthening) 14 3
Midterm Exam 2 2
Time to prepare for Midterm Exam 2 15
Final Exam 1 2
Time to prepare for Final Exam 1 14
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
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Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • ECTS credits and course workload