Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
DRUG METABOLISM 34184063 0 + 0 3.0 3.0

Prerequisites None

Language of Instruction English
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors
Assistants
Goals Examines the drug metabolites formed after taken into the body and their mechanism of formation.
Course Content Introduction to drug metabolism, Factors that effect metabolism, Metabolism pathways, Phase I reactions and their classification, Oxidation reactions and their examples, Reduction and hydrolysis reactions and examples, Phase II reactions and their classification, Glucuronidation reactions, Carcinogenic N-hydroxylamine formation, Sulfation and its examples, Methylation and its examples, Acetylation examples, Amino acid conjugation, Glutathione conjugation, Phase II metabolism.
Learning Outcomes 1) Gains knowledge about drug development by the relationship between chemical structure and biotransformation based on the possible metabolites
2) Evaluate cases about the design, synthesis, analysis and behaviour in biological environment of pharmaceutically active compounds and recommends solutions.
3) Examines the drug metabolites formed after taken into the body and their mechanism of formation.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week Introduction to drug metabolism (biotransformation) Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
2. Week Factors affecting the metabolism Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
3. Week Metabolic pathways, Phase-I reactions and classification Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
4. Week Oxidation, reduction and hydrolysis reaction, and examples Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
5. Week Phase-II reactions and classification Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
6. Week Glucuronidation reactions Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
7. Week The formation of carcinogenic N-hydroxylamines Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
8. Week Sulfation and examples Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
9. Week Methylation and Examples Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
10. Week Acetylation, examples and reasons for occurring hepatic necrosis with some drugs Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
11. Week Amino acid conjugation Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
12. Week The importance of glutathione conjugation in drug metabolism Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
13. Week Phase III metabolism Lecture; Question Answer
Colloquium
Problem Based Learning 		Homework Presentation (Including Preparation Time)
14. Week Final Exam


Sources Used in This Course
Recommended Sources
Kaynak Aksiyon Introduction to Drug Metabolism, Dr G Gordon Gibson, Paul Skett, Cengage Learning; 3Rev Ed edition, 2001.

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3
PY13000
PY23000
PY33000

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 3
Work Hour outside Classroom (Preparation, strengthening) 14 1
Homework 9 1
Presentation (Including Preparation Time) 9 1
Final Exam 1 1
Time to prepare for Final Exam 8 1
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
Quick Access Hızlı Erişim Genişlet
Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • Relations with Education Attainment Program Course Competencies
  • ECTS credits and course workload