Course Information


Course Information
Course Title Code Semester L+U Hour Credits ECTS
EPIGENETICS AND STEM CELLS 56981019 3 + 0 3.0 8.0

Prerequisites None

Language of Instruction English
Course Level Graduate Degree
Course Type Compulsory
Mode of delivery
Course Coordinator
Instructors
Assistants
Goals It is aimed to learn epigenetic concepts from the basics and to examine epigenetic mechanisms in both mammals and vertebrates.
Course Content The course includes basic epigenetic concepts, epigenetic modifications, regulation of epigenetic mechanisms on chromosome, epigenetic controls in gene expression, X chromosome inactivation, importance of epigenetic controls in embryonic and adult stem cell differentiation, epigenetic controls in c.elegans model.
Learning Outcomes 1) Basic concepts in epigenetics are defined.
2) Types of epigenetic modifications are explained in detail.
3) Epigenetic control of stem cells from the embryonic period is explained.

Weekly Topics (Content)
Week Topics Teaching and Learning Methods and Techniques Study Materials
1. Week Basic concepts in epigenetics Lecture

 Homework
2. Week Epigenetic mechanisms and transcription control Lecture

 Homework
3. Week Epigenetic regulation elements in mammalian and C.elegans Lecture

 Homework
4. Week RNAi and heterochromatin assembly Lecture

 Homework
5. Week Epigenetic regulation on the X chromosome Lecture

 Homework
6. Week Chromatin modification and mechanisms of action Lecture

 Homework
7. Week Transcriptional repression threonaxis group proteins Lecture

 Homework
8. Week Histone variants and epigenetics Lecture

 Homework
9. Week Epigenetic controls on sex determination in mammals Lecture

 Homework
10. Week Epigenetic reprogramming Lecture

 Homework
11. Week Laboratory application (stem cell isolation from adipose tissue) Lecture

 Homework
12. Week Epigenetic mechanisms in germinal and pluripotent stem cell lines Lecture

 Homework
13. Week Epigenetic determinants in cancer Lecture

 Homework
14. Week Examination of new studies on epigenetic control of stem cells in the literature Lecture

 Homework

Sources Used in This Course
Recommended Sources
Epigenetics. C. David Allis (Editor), Marie-Laure Caparros (Editor), Thomas Jenuwein (Editor), Danny Reinberg (Editor).Cold Spring Harbor Laboratory Press; 2nd edition (February 28, 2015)

Relations with Education Attainment Program Course Competencies
Program RequirementsContribution LevelDK1DK2DK3
PY15555
PY25555
PY35555
PY45000

*DK = Course's Contrubution.
0 1 2 3 4 5
Level of contribution None Very Low Low Fair High Very High
.

ECTS credits and course workload
Event Quantity Duration (Hour) Total Workload (Hour)
Course Duration (Total weeks*Hours per week) 14 3
Work Hour outside Classroom (Preparation, strengthening) 14 8
Homework 3 6
Presentation (Including Preparation Time) 1 10
Midterm Exam 1 2
Time to prepare for Midterm Exam 1 20
Final Exam 1 3
Time to prepare for Final Exam 1 20
1 2
1 4
Total Workload
Total Workload / 30 (s)
ECTS Credit of the Course
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Course Information
  • Course Information
  • Weekly Topics (Content)
  • Sources Used in This Course
  • Relations with Education Attainment Program Course Competencies
  • ECTS credits and course workload